Polymorphism of exon 20 of the leptin receptor gene and serum leptin concentrations of Nellore heifers raised on pasture


  • Lucas Jacomini Abud
  • Cátia Oliveira Guimarães Abud
  • Maria Clorinda Soares Fioravanti
  • Eduardo de Oliveira Melo
  • Emmanuel Arnhold
  • Fernanda Paulini
  • José Robson Bezerra Sereno




Bos taurus indicus, bovino de corte, hormônio, idade a puberdade, precocidade sexual, reprodução.


The physiological changes that occur at puberty in heifers are objectives of study in order to better understand this phenomenon and to identify alternatives to achieve greater sexual precocity. Among the most important factors that influence puberty the leptin hormone and its receptor can be highlighted, as they are factors that perform communication between the nutritional status and the reproductive axis, and its participation in reproductive physiology is not fully understood. Therefore, the aim of this study was to determine the serum profile of the leptin hormone, to identify polymorphisms at exon 20 of the leptin receptor and associate them with the occurrence of puberty in heifers raised on pasture. We followed 56 heifers for 14 months and carried out the progesterone assay for determining the puberty occurrence, leptin dosage and sequencing of the leptin receptor gene for identifying the occurrence of SNP polymorphisms. Concentration of leptin was compared between the animals puberty with animals not puberty and the hormone of the animals puberty in the pre-pubertal and pubertal periods. After the identification of the polymorphism, the possible interactions of the mutation occurrence in the leptin receptor gene with the leptin concentrations and the puberty were analyzed. After analyzing, no observed correlation between the occurrence of the mutation in the leptin T945M receptor gene and leptin plasma concentrations and the puberty in heifers raised on pasture.




Como Citar

ABUD, L. J.; ABUD, C. O. G.; FIORAVANTI, M. C. S.; MELO, E. de O.; ARNHOLD, E.; PAULINI, F.; SERENO, J. R. B. Polymorphism of exon 20 of the leptin receptor gene and serum leptin concentrations of Nellore heifers raised on pasture. Scientia Agraria Paranaensis, [S. l.], v. 16, n. 4, p. 443–448, 2017. DOI: 10.18188/sap.v16i4.15112. Disponível em: https://e-revista.unioeste.br/index.php/scientiaagraria/article/view/15112. Acesso em: 28 set. 2021.



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