Plant-based approach to combating Dengue Fever: Active compounds, Immunotargets and Mechanism of actions
DOI:
https://doi.org/10.48075/aes.v9i2.34118Keywords:
Vírus da Dengue, Fitoterápicos, Modulação imunológica, Alvos imunológicosAbstract
Background: Dengue fever remains a global health threat, particularly in tropical regions, with no effective vaccines or antiviral treatments available. This review explores plant-based therapies as a promising approach to manage dengue by focusing on bioactive compounds, immunotargets, and mechanisms of action. Aim: The review aims to explore the therapeutic potential of phytomedicines in dengue management, highlighting their antiviral and immune-modulating effects, and addressing the challenges in clinical application. Methods: In this review, a comprehensive literature search was conducted, sourcing peer-reviewed articles on medicinal plants and their bioactive compounds in relation to dengue fever. The review analyzes the interaction of these compounds with key immunotargets and their mechanisms in alleviating dengue symptoms. Results: Plants such as Andrographis paniculata, Azadirachta indica, Carica papaya, Curcuma longa, Tinospora cordifolia, and Euphorbia hirta contain bioactive compounds like flavonoids, alkaloids, terpenoids, and saponins. These compounds inhibit viral replication, modulate immune responses, and target critical immunotargets, including viral proteins and cytokine production. For example, quercetin suppresses viral replication, while berberine reduces pro-inflammatory cytokines, potentially reducing dengue complications. Terpenoids, with their anti-inflammatory properties, can mitigate excessive immune activation. Saponins may enhance antiviral defenses, lowering viral load and disease severity. Conclusion: Phytomedicines offer significant potential as adjunct therapies for dengue, with antiviral and immune-modulating properties. However, challenges related to standardization, quality control, and variability in active compound concentrations must be addressed to ensure their clinical application. Integrating phytomedicines with conventional therapies may provide effective and sustainable strategies for managing dengue globally.
References
Ilic I, Ilic M. Global Patterns of Trends in Incidence and Mortality of Dengue, 1990–2019: An Analysis Based on the Global Burden of Disease Study. Medicina. 2024 Mar 1;60(3):425. https://doi.org/10.3390/medicina60030425
Paz-Bailey et al. Dengue. The Lancet. 2024 Feb 17;403(10427):667-82. DOI: 10.1016/S0140-6736(23)02576-X
Namirimu T, Kim S. Dengue fever: epidemiology, clinical manifestations, diagnosis, and therapeutic strategies. Annals of Clinical Microbiology. 2024 Jun 20;27(2):131-41. https://doi.org/10.5145/ACM.2024.27.2.7
Ali-Seyed M, Vijayaraghavan K. Dengue virus infections and anti-dengue virus activities of Andrographis paniculata. Asian Pacific Journal of Tropical Medicine. 2020 Feb;13(2): 49-55. doi:10.4103/1995-7645.275412
Vidanapathirana M. Dengue haemorrhagic fever in chronic kidney disease and heart failure: challenges in fluid management. Tropical Medicine and Health. 2024 Apr 24;52(1):33. https://doi.org/10.1186/s41182-024-00600-9
Chauhan N et al. Dengue virus: pathogenesis and potential for small molecule inhibitors. Bioscience Reports. 2024 Aug; 44(8):BSR20240134. https://doi.org/10.1042/BSR20240134
Ellan K et al. Anti-viral activity of culinary and medicinal mushroom extracts against dengue virus serotype 2: an in-vitro study. BMC complementary and alternative medicine. 2019 Dec; 19(260):1-2. https://doi.org/10.1186/s12906-019-2629-y
Handagala JK et al. Medicinal Plants Used in Sri Lankan Traditional Medicine for Dengue Fever. Microbiology Research. 2024 Apr 3;15(2):468-88. https://doi.org/10.3390/microbiolres15020032
Alotaibi F et al. Investigating the effects of four medicinal plants against dengue virus through QSAR modeling and molecular dynamics studies. Journal of Biomolecular Structure and Dynamics. 2024 Jan 3:1-8. https://doi.org/10.1080/07391102.2024.2301744
Sreedharan A, Vishnu B. Ayurvedic management of dengue haemorrhagic fever with menorrhagia: A case report. Journal of Ayurveda and Integrative Medicine. 2024 May 1;15(3):100923. https://doi.org/10.1016/j.jaim.2024.100923
Singh N, Yadav SS. Anti-dengue therapeutic potential of Tinospora cordifolia and its bioactives. Journal of Ethnopharmacology. 2024 Apr 26:118242. https://doi.org/10.1016/j.jep.2024.118242
Yudisthira D et al. Potential of Carica papaya leaf extract as a future medicine for thrombocytopenia in dengue patients: from traditional to scientific drug discovery. Advances in Traditional Medicine. 2024 Jun;24(2):389-402. https://doi.org/10.1007/s13596-023-00701-6
Chaughule RS, Barve RS. Role of herbal medicines in the treatment of infectious diseases. Vegetos. 2024 Feb;37(1):41-51. https://doi.org/10.1007/s42535-022-00549-2
Kolkar KP et al. Updates on some medicinal and ornamental plants-Ayurvedic medicines. World Journal of Advanced Research and Reviews. 2024;23(1):111-47. https://doi.org/10.30574/wjarr.2024.23.1.1893
Gangwar M et al. Botanical Warriors: Harnessing Nature's Antiviral Arsenal-A Comprehensive Study of Medicinal Plants Combatting Pathogenic Viral Infections. Pharmacological Research-Natural Products. 2024 Apr 7:100043. https://doi.org/10.1016/j.prenap.2024.100043
Ajaegbu EE, Ikegbuna CP. Potential medicinal plants for the treatment of dengue fever: a systematic review. Preprints. 2023;2023110833. https://doi.org/10.20944/preprints202311.0833.v1
Altamish M et al. Therapeutic potential of medicinal plants against dengue infection: A mechanistic viewpoint. ACS Omega. 2022 Jul 6;7(28):24048–65. https://doi.org/10.1021/acsomega.2c00625
Akwayamai JJ et al. A review of medicinal plants with anti-dengue virus activity. European Journal of Pharmaceutical Research. 2022; 2(2):1-11. doi:10.24018/ejpharma.2022.2.2.20.
Chavda VP et al. Ayurvedic and other herbal remedies for dengue: An update. Clinical Complementary Medicine and Pharmacology. 2022;2(3): 100024. https://doi.org/10.1016/j.ccmp.2022.100024
Jain P, Singh Y, Kumari R. In silico investigation and MD simulations of phytochemicals of C. wightii against dengue targets NS5 and E protein. Vegetos. 2024 Jun;37(3):1166-84. https://doi.org/10.1007/s42535-023-00658-6
Baranwal J et al. Utilization of Phytochemicals as Nutraceutical in the Prophylaxis of Dengue. Pharmaceutical Chemistry Journal. 2024 Apr 17:1-8. https://doi.org/10.1007/s11094-024-03105-1
Purohit P et al. Evaluation of the inhibitory potency of anti-dengue phytocompounds against DENV-2 NS2B-NS3 protease: virtual screening, ADMET profiling and molecular dynamics simulation investigations. Journal of Biomolecular Structure and Dynamics. 2024 Apr 12;42(6):2990-3009. https://doi.org/10.1080/07391102.2023.2212798
Dhiman M et al. Traditional knowledge to contemporary medication in the treatment of infectious disease dengue: a review. Frontiers in Pharmacology. 2022;13:750494. https://doi.org/10.3389/fphar.2022.750494
Islam MT et al. In silico-based identification of natural inhibitors from traditionally used medicinal plants that can inhibit dengue infection. Molecular Biotechnology. 2024 Jun 4:1-7. https://doi.org/10.1007/s12033-024-01204-8
Kamaraj C et al. Exploring the therapeutic potential of traditional antimalarial and antidengue plants: a mechanistic perspective. Canadian Journal of Infectious Diseases and Medical Microbiology. 2023(1):1860084. https://doi.org/10.1155/2023/1860084
Saleh MS, Kamisah Y. Potential medicinal plants for the treatment of dengue fever and severe acute respiratory syndrome-coronavirus. Biomolecules. 2020 Dec 30;11(1):42. https://doi.org/10.3390/biom11010042
Khan M et al. Antiviral potential of traditional unani medicine with special emphasis on dengue: a review. Current Drug Targets. 2023 Dec 1;24(17):1317-34. https://doi.org/10.2174/0113894501257577231103044735
Lavanya D et al. Bio-therapeutic intervention for dengue infection-present scenario on plant-based remedies: A review article. International Journal of Agricultural Technology. 2024;20(2):597-618. Available from: http://www.ijat-aatsea.com/pdf/v20_n2_2024_March/11_IJAT_20(2)_2024_Lavanya,%20D.(KS).pdf
Shivendra Kumar SK et al. Molecular herbal inhibitors of dengue virus: an update. International Journal of Medicinal and Aromatic Plants. 2012;2(1):1-21. Available from: https://www.cabidigitallibrary.org/doi/full/10.5555/20123300107
Rosmalena R et al. The antiviral effect of Indonesian medicinal plant extracts against dengue virus in vitro and in silico. Pathogens. 2019; 8(2):85. https://doi.org/10.3390/pathogens8020085
Kaushik S et al. Antiviral and therapeutic uses of medicinal plants and their derivatives against dengue viruses. Pharmacognosy Reviews. 2018 Jul 1;12(24). Available from: https://phcogrev.com/sites/default/files/PhcogRev_2018_12_24_177.pdf
Neelawala D, Rajapakse S, Kumbukgolla WW. Potential of medicinal plants to treat dengue. Int J One Health. 2019;5:86-91. doi:10.14202/IJOH.2019.86-91
Perera WP et al. Antiviral potential of selected medicinal herbs and their isolated natural products. BioMed research international. 2021;2021(1):7872406. https://doi.org/10.1155/2021/7872406
Al Quwatli L et al. Antiviral activity of Withanolide against different infectivity phases of dengue virus serotype 2 in vero cell line. Revista Brasileira de Farmacognosia. 2024 Jun;34(3):609-617. https://doi.org/10.1007/s43450-023-00510-7
Roney M, Aluwi MF. Computational studies demonstrating dithymoquinone of Nigella sativa as a potential anti-dengue agent: Short review. Intelligent Pharmacy. 2024 Feb 20. https://doi.org/10.1016/j.ipha.2024.02.006
Lee MF et al. Molecular docking and dynamics simulation reveal withanolides as potent antivirals against dengue virus. South African Journal of Botany. 2024 Jun 1;169:426-34. https://doi.org/10.1016/j.sajb.2024.04.045
Rani JM et al. Anti-viral effectuality of plant polyphenols against mutated dengue protein NS2B47-NS3: a computational exploration. Gene Reports. 2022 Jun 1;27:101546. https://doi.org/10.1016/j.genrep.2022.101546
Saleem HN et al. Inhibition of dengue virus protease by eugeniin, isobiflorin, and biflorin isolated from the flower buds of Syzygium aromaticum (Cloves). Acs Omega. 2019 Jan 17;4(1):1525-3. https://doi.org/10.1021/acsomega.8b02861
Shukla R et al. Cocculus hirsutus-derived phytopharmaceutical drug has potent anti-dengue activity. Frontiers in Microbiology. 2021 Nov 29;12:746110. https://doi.org/10.3389/fmicb.2021.746110
Silva-Trujillo L et al. Essential oils from Colombian plants: Antiviral potential against dengue virus based on chemical composition, in vitro and in silico analyses. Molecules. 2022 Oct 12;27(20):6844. https://doi.org/10.3390/molecules27206844
Tian C et al. Identification of an effective fraction from Ampelopsis Radix with anti-dengue virus activities in vitro and in vivo. Journal of Ethnopharmacology. 2023 Jun 12;309:116339. https://doi.org/10.1016/j.jep.2023.116339 Gómez-Calderón C, Mesa-Castro C,
Robledo S. et al. Antiviral effect of compounds derived from the seeds of Mammea americana and Tabernaemontana cymosa on Dengue and Chikungunya virus infections. BMC complementary and alternative medicine. 2017 Dec;17:1-2. https://doi.org/10.1186/s12906-017-1562-1
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Acta Elit Salutis
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Aviso de Direito Autoral Creative Commons
Política para Periódicos de Acesso Livre
Autores que publicam nesta revista concordam com os seguintes termos:
1. Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.2. Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
3. Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado (Veja O Efeito do Acesso Livre).
Licença Creative Commons
Esta obra está licenciada com uma Licença Creative Commons Atribuição-NãoComercial-CompartilhaIgual 4.0 Internacional, o que permite compartilhar, copiar, distribuir, exibir, reproduzir, a totalidade ou partes desde que não tenha objetivo comercial e sejam citados os autores e a fonte.
